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KMID : 1007320070130030200
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Journal of the Korean Society of Menopause
2007 Volume.13 No. 3 p.200 ~ p.208
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The Effects of Estrogen Replacement Therapy on Serum Lipid Profile in Surgically Menopaused Women
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Kim Hwi-Gon
Kim Seong-Chol
Lee Kyu-Sup
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Abstract
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Objectives: To evaluate short-term and long-term effects of estrogen replacement therapy (ERT) on lipid profile in surgically menopaused women.
Methods: In this cross-sectional study, 120 surgically menopaused women after total hysterectomy and bilateral oophorectomy and 107 natural postmenopausal women were enrolled. After surgical menopause, 28 women received 0.625 mg conjugated equine estrogen (CEE) and 32 women did not for 3 months, 28 women received and 32 women were did not for 1 year. Natural postmenopausal women received 0.625 mg conjugated equine estrogen (CEE) and 5 mg medroxyprogesterone acetate (MPA). The effects of hormone therapy on plasma levels of lipids were investigated.
Results: During hormone therapy, total cholesterol and LDL cholesterol level decreased significantly for 3 months and 1 year in surgically menopaused women (P＜0.05). HDL cholesterol level raised at 3 months but there was not significant statistical difference (P＞0.05). Triglyceride level decreased in surgically menopaused women had not received ERT but there was no significant statistical difference (P＞0.05).
Conclusion: The results of our study results suggest that ERT had more beneficial effects on lipid profile in surgically menopaused women.
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KEYWORD
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Estrogen replacement therapy, Lipid profile, Surgically menopaused women
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